Glasgow grew from a small rural settlement on the River Clyde to become one of the largest seaports in the world. Expanding from the medieval bishopric and royal burgh, and the later establishment of the University of Glasgow in the 15th century, it became a major centre of the Scottish Enlightenment in the 18th century. From the 18th century the city also grew as one of Great Britain's main hubs of transatlantic trade with North America and the West Indies.
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