Osaka About this sound listen is a city in the Kansai region of Japan's main island of Honshu, a designated city under the Local Autonomy Law, the capital city of Osaka Prefecture and also the largest part of the Keihanshin metropolis, which comprises three major cities of Japan: Kyoto, Osaka and Kobe. Located at the mouth of the Yodo River on Osaka Bay, Osaka is Japan's third largest city by population after Tokyo and Yokohama.
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